Weird Engineered Organism Has 6-Letter DNA

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The first report of a bacterium whose genome contains man-made DNA building blocks opens the door for tailor-made organisms that could be used to produce new drugs and other products.

All living creatures have a DNA "alphabet" of just four letters, which encode instructions for the proteins that perform most of the key jobs inside cells. But expanding that alphabet to include artificial letters could give organisms the ability to produce new proteins never seen before in nature.

It's called epigenetics, and according to new research it can influence everything from a human's weight to a small animal's propensity to fall in love.
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The man-made DNA could be used for everything from the manufacture of new drugs and vaccines to forensics, researchers say.

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"What we have done is successfully store increased information in the DNA of a living cell," study leader Floyd Romesberg, a chemical biologist at The Scripps Research Institute in La Jolla, Calif., told Live Science. Yet many steps remain before Romesberg and his colleagues can get cells to produce artificial proteins. [Biomimicry: 7 Clever Technologies Inspired by Nature]

DNA alphabet

The field of synthetic biology involves tinkering with DNA to create organisms capable of novel functions in medicine, energy and other areas.

The DNA alphabet consists of four letters, or bases: adenine, thymine, guanine and cytosine (A, T, G and C). Adenine pairs with thymine, and guanine pairs with cytosine. RNA is a genetic material similar to DNA, except it has a different chemical backbone and replaces the base thymine with uracil (U).

Living things translate DNA into proteins through a series of steps. First, enzymes "transcribe" the DNA into RNA. Then, structures called ribosomes translate the DNA into proteins, which are made up of strands of molecules called amino acids.

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Ultimately, the researchers aim to create organisms that can produce artificial proteins. But first, they need to show that the DNA containing the man-made letters can be transcribed into RNA, and that this RNA can be translated into proteins.

In the study, Romesberg and his team created an new pair of DNA letters not found in nature and inserted the pair into cells of Escherichia coli bacteria. Getting the DNA into the cells is not easy, but the researchers were able to do it by way of a transporter, a protein that moves materials across cell membranes.

Tags genetics DNA